Description:

Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabolism, and excretion. Primary goals of clinical pharmacokinetics include enhancing efficacy and decreasing toxicity of a patient's drug therapy. Listen to pronunciation. The activity of drugs in the body over a period of time, including the processes by which drugs are absorbed, distributed in the body, localized in the tissues, and excreted. Pharmacokinetics is a science that studies how certain substances affect a living organism when administered. This particular science determines what happens to a drug from the time it is administered throughout its circulation within the body and to the moment when it is ultimately eliminated from the body.

Pharmacokinetics, sometimes described as what the body does to a drug, refers to the movement of a drug into, though, and out of the body the time course of its absorption, bioavailability, distribution, metabolism, and excretion. Pharmacokinetics is the aspect of pharmacology dealing with how drugs reach their site of action and are removed from the body. The following processes govern the rate of accumulation and removal of drugs from an organism–absorption, distribution, metabolism, and excretion. Pharmacokinetic modeling is performed by no compartmental or compartmental methods. No compartmental methods estimate the exposure to a drug by estimating the area under the curve of a concentration-time graph. Compartmental methods estimate the concentration-time graph using kinetic models.

Pharmacokinetic parameters are assessed by monitoring variations in the concentration of the drug and/or its metabolites in physiological fluids that are easy to access (i.e., plasma and urine). Plasma concentrations are usually checked, and in addition, biopsies can be taken from animals and sometimes from humans.

The pharmacokinetics of a drug depends on patient-related factors as well as on the drug's chemical properties. Some patient-related factors (eg, renal function, genetic makeup, sex, age) can be used to predict the pharmacokinetic parameters in populations. Distribution in pharmacology is a branch of pharmacokinetics that describes the reversible transfer of a drug from one location to another within the body. Each organ or tissue can receive different doses of the drug and the drug can remain in the different organs or tissues for a varying amount of time.

Pharmacokinetics, sometimes described as what the body does to a drug, refers to the movement of a drug into, though, and out of the body the time course of its absorption, bioavailability, distribution, metabolism, and excretion. Drug pharmacokinetics determines the onset, duration, and intensity of a drug's effect.

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